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Center of Structural Mass Spectrometry
CTP
Center of Structural Mass Spectrometry
© Christian Arlt


Structural mass spectrometry (MS) is gaining increasing importance for deriving valuable three-dimensional structural information on proteins and protein complexes, and it complements existing techniques, such as NMR spectroscopy and X-ray crystallography. Structural MS unites different MS-based techniques, such as hydrogen/deuterium exchange, native MS, ion-mobility MS, protein footprinting, and chemical cross-linking/MS, and it allows fundamental questions in structural biology to be addressed.


In the Center of Structural MS, we focus on the cross-linking/MS strategy. This method not only delivers tertiary structural information on proteins, but is also increasingly being used to decipher protein interaction networks, both in vitro and in vivo. Cross-linking/MS is currently one of the most promising MS-based approaches to derive structural information on very lage and transient protein assemblies and intrinsically disordered proteins.

COSP2
Center of Structural Mass Spectrometry
© Christian Arlt
COSP2
COSP2
© 2019 Sinz-Lab