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Original Papers

Hage C, Falvo F, Schäfer M, Sinz A., Novel Concepts of MS-Cleavable Cross-linkers for Improved Peptide Structure Analysis. J Am Soc Mass Spectrom. 2017 Jun 26. doi: 10.1007/s13361-017-1712-1. [Epub ahead of print]. PubMed.

Bilova T, Paudel G, Shilyaev N, Schmidt R, Brauch D, Tarakhovskaya E, Milrud S, Smolikova G, Tissier A, Vogt T, Sinz A, Brandt W, Birkemeyer C, Wessjohann LA, Frolov A., Global Proteomic Analysis of Advanced Glycation End Products in the Arabidopsis Proteome Provides Evidence for Age-related Glycation Hotspots. J Biol Chem. 2017 Jun 13. pii: jbc.M117.794537. doi: 10.1074/jbc.M117.794537. [Epub ahead of print]. PubMed.

Lindner S, Gruhle K, Schmidt R, Garamus VM, Ramsbeck D, Hause G, Meister A, Sinz A, Drescher S., Azide-Modified Membrane Lipids: Synthesis, Properties, and Reactivity. Langmuir. 2017 May 23;33(20):4960-4973. doi: 10.1021/acs.langmuir.7b00228. PubMed.

Häupl B, Ihling CH, Sinz A., Combining affinity enrichment, cross-linking with photo-amino acids, and mass spectrometry for probing protein kinase D2 interactions. Proteomics. 2017 Apr 7. doi: 10.1002/pmic.201600459. [Epub ahead of print]. PubMed.

Lipstein N, Göth M, Piotrowski C, Pagel K, Sinz A, Jahn O., Presynaptic Calmodulin targets: lessons from structural proteomics. Expert Rev Proteomics. 2017 Mar 14. doi: 10.1080/14789450.2017.1275966. PubMed.

Schmidt R., Sinz A., Improved single-step enrichment methods of cross-linked products for protein structure analysis and protein interaction mapping. Anal Bioanal Chem. 2017 Jan 12. doi: 10.1007/s00216-017-0185-1. [Epub ahead of print] PubMed.

Arlt C, Flegler V, Ihling CH, Schäfer M, Thondorf I, Sinz A., An Integrated Mass Spectrometry-Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor. Angew Chem Int Ed Engl. 2016 Nov 29. doi: 10.1002/ange.201609826. PubMed.

Paudel G., Bilova T., Schmidt R., Greifenhagen U., Berger R., Tarakhovskaya E., Stöckhardt S., Balcke GU., Humbeck K., Brandt W., Sinz A., Vogt T., Birkemeyer C., Wessjohann L., Frolov A., Osmotic stress is accompanied by protein glycation in Arabidopsis thaliana. J Exp Bot. 2016 Dec;67(22):6283-6295. PubMed

Buttstedt A., Ihling CH., Pietzsch M., Moritz RF., Royalactin is not a royal making of a queen. Nature. 2016 Sep 21;537(7621):E10-2. doi: 10.1038/nature 19349. PubMed

Schumann, M., Ihling, C.H., Prell, E., Schierhorn, A., Sinz, A., Fischer G, Schiene-Fischer C, Malešević M., Identification of low abundance cyclophilins in human plasma. Proteomics 2016, doi: 10.1002/pmic.201600221. Online

Kölbel, K., Warnke, S., Seo, J., von Helden, G., Moretti, R., Meiler, J., Pagel, K., Sinz, A., Conformational Shift of a β-Hairpin Peptide upon Complex Formation with an Oligo–proline Peptide Studied by Mass Spectrometry. ChemistrySelect 2016, doi: 10.1002/slct.201600934. Online

Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A., Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines. Proteomics 2016 Aug 28. PubMed

Häupl B , Ihling CH, Sinz A., Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-linking/Mass Spectrometry . J Proteome Res. 2016 Aug 25. [Epub ahead of print]. PubMed

Arlt C, Goetze M, Ihling CH, Hage C, Schaefer M, Sinz A., Integrated Workflow for Structural Proteomics Studies Based on Cross-Linking/Mass Spectrometry with an MS/MS Cleavable Cross-Linker. Anal Chem. 2016 Aug 16;88(16):7930-7. PubMed

Hage C, Ihling CH, Götze M, Schäfer M, Sinz A., Dissociation Behavior of a TEMPO-Active Ester Cross-Linker for Peptide Structure Analysis by Free Radical Initiated Peptide Sequencing (FRIPS) in Negative ESI-MS. J Am Soc Mass Spectrom. 2016 Jul 14. [Epub ahead of print]. PubMed

Schwarz R, Tänzler D, Ihling CH, Sinz A., Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding. PLoS One. 2016 Mar 18;11(3):e0151412. doi: 10.1371/journal.pone.0151412. eCollection 2016. PubMed

Lössl P, Sinz A., Combining Amine-Reactive Cross-Linkers and Photo-Reactive Amino Acids for 3D-Structure Analysis of Proteins and Protein Complexes. Methos Mol Biol. 2016; 1394: 109-27. PubMed

Köhn M, Ihling CH, Sinz A, Krohn K, Hüttelmaier S., The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 2015 Oct 1;29(19):1998-2003. PubMed

Ihling A, Ihling CH, Sinz A, Gekle M., Acidosis-Induced Changes in Proteome Patterns of the Prostate Cancer-Derived Tumor Cell Line AT-1. J Proteome Res. 2015 Sep 4;14(9):3996-4004. PubMed

Sinz A, Arlt C, Chorev D, Sharon M., Chemical Cross-Linking and Native Mass Spectrometry: A Fruitful Combination for Structural Biology. Protein Sci. Aug;24(8):1193-209. PubMed

Ihling CH, Falvo F, Kratochvil I, Sinz A, Schäfer M., Dissociation behavior of a bifunctional tempo-active ester reagent for peptide structure analysis by free radical initiated peptide sequencing (FRIPS) mass spectrometry. J Mass Spectrom. 2015 Feb; 50(2): 396-406. PubMed

Piotrowski C, Ihling CH, Sinz A., Extending the cross-linking/mass spectrometry strategy: Facile incorporation of photo-activatable amino acids into the model protein calmodulin in Escherichia coli cells. Proteomics. 2015 Feb 26. pii: S1046-2023(15)00055-9. [Epub ahead of print]PubMed

Arlt C, Ihling CH, Sinz A., Structure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry. Proteomics. 2015 Aug; 15(16):2746-55. PuMed

Götze, M., Pettelkau, J., Fritzsche R., Ihling, CH., Schäfer, M., Sinz, A., Automated Assignment of MS/MS Cleavable Cross-Links in Protein 3D-Structure Analysis. J Am Soc Mass Spectrom. 2015 Jan;26(1):83-97. PubMed

Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A., Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. PLoS One. 9 e112886. doi: 10.1371/journal.pone.0112886 eCollection (2014) PubMed

Zorn, M ., Ihling, CH., Golbik, R., Sawers, RG., Sinz, A., Mapping Cell Envelope and Periplasm Protein Interactions of Escherichia coli Respiratory Formate Dehydrogenases by Chemical Cross-linking and Mass Spectrometry. J Proteome Res. 2014 Dec 5;13(12):5524-35. PubMed

Pettelkau, J., Ihling, CH., Frohberg, P., van Werven, L., Sinz, A., Reliable Identification of Cross-Linked Products in Protein Interaction Studies by (13)C-Labeled p-Benzoylphenylalanine. J Am Soc Mass Spectrom. 25 1628-1641 (2014) PubMed

Doberenz, C., Zorn, M., Falke, D., Nannemann, D., Hunger, D., Beyer, L., Ihling, CH., Meiler, J., Sinz, A., Sawers, RG., Pyruvate Formate-Lyase Interacts Directly with the Formate Channel FocA to Regulate Formate Translocation. J Mol Biol. 426 2827-2839 (2014) PubMed

Herbst, S., Lipstein, N., Jahn, O., Sinz, A., Structural Insights into calmodulin/Munc13 interaction. Biol Chem. 395 763-768 (2014) PubMed

Ihling, CH., Schröder, T., Pettelkau, J., Tischer, A., Sinz, A., Accessibilities of N-terminal myristoyl chain and cysteines in guanylyl cyclase-activating protein-2 (GCAP-2) studied by covalent lableing and mass spectrometry. Rapid Commun Mass Spectrom. 28 835-838 (2014) PubMed

Simon, C., Klose, T., Herbst, S., Han, BG., , Sinz, A., Glaeser, RM., Stubbs, MT., Lilie, H., Disulfide Linkage and Structure of Highly Stable Yeast-derived Virus-Particles of Murine Polyomavirus. J Biol Chem. 289 10411-10418 (2014) PubMed

Herbst, S., Maucher, D., Schneider, M. , Ihling, CH., Jahn, O., Sinz, A., Munc13-2-Like skMLCK Variants Cannot Mimic the Unique Calmodulin Binding Mode of Munc13 as Evidenced by Chemical Cross-Linking and Mass Spectrometry. PLoS One. 8 e75119 (2013) PubMed entry

Herbst, S., Masada, N., Pfennig, S., Ihling CH., Cooper, D., Sinz, A., Structural insights into calmodulin/adenylyl cyclase 8 interaction. Anal Bioanal Chem. 405 9333-9342 (2013) PubMed entry

Pettelkau, J. , Thondorf, I., D., Theisgen, S., Lilie, H., Schröder, T., Arlt, C., Ihling, CH., Sinz, A., Structural Analysis of Guanylyl Cyclase-Activating Protein-2 (GCAP-2) Homodimer by Stable Isotope-Labeling, Chemical Cross-Linking, and Mass Spectrometry. J Am Soc Mass Spectrom. 24 1967-1979 (2013) PubMed entry

Schwarz, R., Tänzler, D., Ihling, CH., Müller, MQ., Kölbel, K., Sinz, A., Monitoring Conformational Changes in Peroxysome Proliferator-Activated Receptor alpha by a Genetically Encoded Photo-Amino Acid, Cross-Linking and Mass Spectrometry. J Med Chem. 56 4252-4263 (2013) PubMed entry

Zorn, M., Ihling, CH., Golbik, R., Sawers, RG., Sinz, A., Selective selC-Independent Selenocysteine Incorporation into Formate Dehydrogenases. PLoS One. 8 e61913 (2013) PubMed entry

Buttstedt A., Wostradowski, T., Ihling, C., Hause, G., Sinz, A., Schwarz, E., Different morphology of amyloid fibrils originating from agitated and non-agitated conditions. Amyloid. 20 86-92 (2013) PubMed entry

Wolf, A., Rietscher, K., Glaß, M., Hüttelmaier, S., Schutkowski, M., , Ihling, C., Sinz A., Wingenfeld, A., Mun, A., Hatzfeld, M., V., Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci. 126 1832-1844 (2013) PubMed entry

Lechner, M., Marz, M., Ihling, C., Sinz A., Stadler, PF., Krauss, V., The correlation of genome size and DNA methylation rate in metazoans . Theory Biosci. 132 47-60 (2012) PubMed entry

Masada, N., Schaks, S., Jackson, SE., Sinz, A., Cooper, DM., Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8 . Biochemistry 51 7917-7929 (2012) PubMed entry

Lipstein, N., Schaks, S., Dimova, K., Kalkhof, S., Ihling, C., Kölbel, K., Ashery, U., Rhee, J., Brose, N., Sinz, A., Jahn, O., Non-conserved Ca2+/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Mol Cell Biol. 32 4628-4641 (2012) PubMed entry

Kölbel, K., Ihling, C.H., Sinz, A., Analysis of Peptide Secondary Structures by Photoactivatable Amino Acid Analogs Angew. Chem.- Int Edit 51 12602-12605 (2012) PubMed entry

Kölbel, K., Ihling, C.H., Kühn, U., Neundorf, I., Otto, S., Stichel, J., Robaa, D., Beck-Sickinger, A.G., Sinz, A.,Wahle, E., Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I. Biochemistry 51 5463-5475 (2012) PubMed entry

Sproß, J., Brauch, S., Mandel, F., Wagner, M., Buckenmaier, S., Westermann, B ., Sinz, A., Multidimensional nano-HPLC coupled with tandem mass spectrometry for analyzing biotinylated proteins . Anal Bioanal Chem. Epub ahead of print (2012) PubMed entry

Pettelkau, J., Schroeder, T., Ihling, C.H., Olausson, B.E., Kölbel, K., Lange, C., Sinz, A., Structural Insights into Retinal Guanylylcyclase / GCAP-2 Interaction by Cross-Linking and Mass Spectrometry. Biochemistry 51 4932-4949 (2012) PubMed entry

Fritzsche, R., Ihling C.H., Götze, M., Sinz, A., Optimizing the enrichment of cross-linked products for mass spectrometric protein analysis . Rapid Commun Mass Spectrom . 26 653-658 (2012) PubMed entry

Sproß, J., Sinz, A., Monolithic columns with immobilized monomeric avidin: preparation and application for affinity chromatography . Anal Bioanal Chem. 402 2395-405 (2012) PubMed entry

Krause, K., Boisnard, A., Ihling, C., Ludgate, M., Eszlinger, M., Krohn, Sinz, A., Fuhrer, D., Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid. Int J Biochem Cell Biol . 179 3066-3074 (2012) PubMed entry

Götze, M., Pettelkau, J., Schaks, S., Bosse, K., Ihling, C.H., Krauth, F., Fritzsche, R., Kühn, U., Sinz., A., StavroX - A Software for Analyzing Crosslinked Products in Protein Interaction Studies. J Am Soc Mass Spectrom. 23 76-87 (2012) PubMed entry, http://www.stavrox.com/

Soboh, B., Pinske, C ., Kuhns, M., Waclawek, M., Ihling, C., Trchounian, K., Sinz, A., Sawers, R.G., The respiratory molybdo-selenoprotein formate dehydrogenase of Escherichia coli have hydrogen: benzyl viologen oxidoreductase activity . BMC Microbiol . 11 173-184 (2011) PubMed entry

Pinske, C ., Krüger, S., Soboh, B., Ihling, C., Kuhns, M., Baussemann, M., Jaroschinsky, M., Sauer, C., Sargent, F., Sinz, A., Sawers, R.G., Efficient electron transfer from hydrogen to benzyl viologen by the [NiFe]-hydrogenases of Escherichia coli is dependent on the coexpression of the iron-sulfur cluster-containing small subunit . Arch Microbiol. 193 893-903 (2011) PubMed entry

Kuhfahl, S., Hauburger, A., Thieme, T., Groppe, J., Ihling, C., Tomic, S., Schutkowski, M., Sinz, A., Schwarz,E., Identification of a core domain within the proregion of bone morphogenetic proteins that interact with the dimeric, mature domain . Biochem Biophys Res Commun 408 300-305 (2011) PubMed entry

Nimpsch, A., Schibur, S., Ihling, C., Riemer, T., Huster, D., Schiller, J., Quantitative analysis of denatured collagen by collagenase digestion and subsequent MALDO-TOF mass spectrometry. Cell Tissue Res. 343, 605-617 (2011) PubMed entry

Müller, M.Q., Zeiser J.J., Dreiocker, F., Pich, A., Schäfer, M, Sinz, A., A universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis. Rapid Commun Mass Spectrom. 25, 155 –161 (2011) PubMed entry

Kalkhof, S., Witte, K., Ihling, C. H., Müller, M. Q., Keller, M. V., Haehn, S., Smyth, N., Paulsson, M., Sinz, A., A Novel Disulfide Pattern in Laminin-Type Epidermal Growth Factor-like (LE) Modules of Laminin β1 and γ1 Chains. Biochemistry 49, 8359–8366 (2010) PubMed entry

Müller, M.Q., Dreiocker, F., Ihling, C.H., Schäfer, M., Sinz, A., Cleavable Cross-Linker for Protein Structure Analysis: Reliable Identification of Cross-Linking Products by Tandem MS, Anal. Chem. 82, 6958–6968 (2010) PubMed entry

Kalkhof, S., Haehn, S., Paulsson, M., Smyth, N., Meiler, J., Sinz, A., Computational Modeling of Laminin N-Terminal Domains Using Sparse Distance Constraints from Disulfide Bonds and Chemical Cross-Linking, Proteins: Structure, Function and Bioinformatics 78 3409-3427 (2010) PubMed entry

Schröder-Tittmann, K., Bosse-Doenecke, E., Reedtz-Runge, S., Ihling, C., Sinz, A., Tittmann, K., Rudolph, R. Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon-like peptide-1 receptor. Biochemistry 49, 7956–7965 (2010) PubMed entry

Müller, M.Q., Dreiocker, F., Ihling, C.H., Schäfer, M., Sinz, A. Fragmentation Behavior of a Thiourea-Based Reagent for Protein Structure Analysis by Collision-Induced Dissociative Chemical Cross-Linking. J. Mass Spectrom. 45, 880–891 (2010) PubMed entry

Temme, C., Zhang, L., Kremmer, E., Ihling, C., Chartier, A., Sinz, A., Simonelig, M., Wahle, E. Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.
RNA
16, 1356–243 (2010) PubMed entry

Hoffmann, A., Müller, M.Q., Gloser, M., Sinz, A., Rudolph, R., Pfeifer, S. Recombinant Production of Bioactive Human TNF-alpha by SUMO-fusion system – High Yields from Shake-flask Culture. Protein Expr. Purif. 72, 238–243 (2010). PubMed entry

Sproß, J. and Sinz, A. A Capillary Monolithic Trypsin Reactor for Efficient Protein Digestion in Online and Offline Coupling to ESI and MALDI Mass Spectrometry. Anal. Chem. 82, 1434–1443 (2010) PubMed entry

Krauth, F., Dahse, H.M., Rüttinger, H.H., Frohberg, P. Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity. Bioorg. Med. Chem., 18, 1816–1821 (2010). PubMed entry

Dreiocker, F.*, Müller, M.Q.*, Sinz, A., Schäfer, M., Collision-Induced Dissociative Chemical Cross-Linking Reagent for Protein Structure Characterization: Applied Edman Chemistry in the Gas Phase.  J. Mass Spectrom. 45, 178–189 (2010) PubMed entry
* both authors contributed equally

Sproß, J. and Sinz, A., Immobilized Monolithic Enzyme Reactors for Application in Proteomics and Pharmaceutics. Anal. Bioanal. Chem. 395, 1583–1588 (2009) PubMed entry

Krauth, F., Ihling, C., Rüttinger, H.H. and Sinz, A., Heterobifunctional Isotope-labeled Amine-Reactive Photo-Cross-Linker for Structural Investigation of Proteins by MALDI-TOF/TOF and ESI-LTQ-Orbitrap Mass Spectrometry. Rapid Commun. Mass Spectrom. 23, 2811–2818 (2009) PubMed entry

Dimova, K., Kalkhof, S., Pottratz, I., Ihling, C., Rodriguez-Castaneda, F., Liepold, T., Griesinger, C., Brose, N., Sinz, A., and Jahn, O. Structural Insights into the Calmodulin-Munc13 Interaction Obtained by Cross-Linking and Mass Spectrometry. Biochemistry 38, 5908–5921 (2009) PubMed entry

Müller, M.Q., de Koning, L.J., Schmidt, A., Ihling, C., Syha, Y., Rau, O., Mechtler, K., Schubert-Zsilavecz, M., and Sinz, A., An Innovative Method to Study Target Protein-Drug Interactions by Mass Spectrometry. J. Med. Chem. 52, 2875–2879 (2009) PubMed entry

Bauer, K., Kretzschmar, A.K., Cvijic, H., Blumert, C., Löffler, D., Brocke-
Heidrich, K., Schiene-Fischer, C., Fischer, G., Sinz, A., Clevenger, C.V. and Horn , F., Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. Oncogene 28, 2784–2795 (2009) PubMed entry

Manolaridis, I.,  Mumtsidu, E.,  Konarev, P., Makhov, A.M., Fullerton, S.F., Sinz, A., Kalkhof, S., McGeehan, J.E.,  Carey, P.D., Griffith, J.D., Svergun, D.  Kneale, G.G. and Tucker, P.A., Structural and Biophysical Characterization of the Components of the Herpes Simplex Virus-1 Replication Origin. J. Biol. Chem. 284, 16343–16353 (2009) PubMed entry

MacDougall, D., Wachten, S., Ciruela, A., Sinz, A. and Cooper, D.M.F., Separate Elements within a Single IQ-like Motif in Adenylyl Cyclase Type 8 Impart Ca2+/CaM Stimulation and Autoinhibition. J. Biol. Chem. 284, 15573–15588 (2009) PubMed entry

Krauth, F., Friedemann, R., Rüttinger, H.H., and Frohberg, P. Open-chain and cyclic amidrazones forming persistent radicals. An electrochemical and quantum chemical study. ARKIVOC VII, 150–164 (2009)

Kölbel, K., Ihling, C., Bellmann-Sickert, K., Neundorf, I., Beck-Sickinger, A. G., Sinz, A., Kühn, U., and Wahle, E. Type I protein arginine methyl transferases PRMT1 and 3 act distributively.
J. Biol. Chem. 284, 8274–8282 (2009) PubMed entry

Müller, M.Q., Roth, C., Sträter, N. and Sinz, A., Expression and Purification of the Ligand-Binding Domain of Peroxisome Proliferator-Activated Receptor alpha. Protein Expr. Purif. 62, 185–189 (2008) PubMed entry

Kalkhof, S. and Sinz, A., Chances and Pitfalls of Chemical Cross-Linking with Amine-Reactive N-Hydroxy Succinimide Esters. Anal. Bioanal. Chem. 392, 305–312 (2008) PubMed entry

Kalkhof, S., Haehn, S., Ihling, C., Smyth, N. and Sinz, A., Determination of Disulfide Bond Patterns in Laminin ß1 Chain N-Terminal Domains by Nano-High Performance Liquid Chromatography/Matrix-Assisted Laser Desorption/Ionization Time-of-Flight/Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 22, 1933–1940 (2008) PubMed entry

Schulz, D.M., Kalkhof, S., Schmidt, A., Ihling, C., Stingl, C., Mechtler, K., Zschörnig, O. and Sinz, A., Annexin A2/p11 Interaction: New insights Into Annexin A2 Tetramer Structure by Chemical Cross-Linking, High-Resolution Mass Spectrometry, and Computational Modeling. Proteins 69, 254–269 (2007) PubMed entry

Pluder, F., Sinz, A. and Beck-Sickinger, A.G., Proliferative Effect of Calcitonin Gene-related Peptide is Induced by at least Five Proteins as Identified by Proteome Profiling. Chem. Biol. Drug Des. 69, 14–22 (2007) PubMed entry

Stingl, C.*, Ihling, C.*, Ammerer, G., Sinz, A. and Mechtler, K., Application of Different Fragmentation Techniques for the Analysis of Phosphopeptides using a Hybrid Linear Ion Trap-FTICR Mass Spectrometer. Biochim. Biophys. Acta- Proteins and Proteomics 1764, 1842–1852 (2006) PubMed entry
* both authors contributed equally

Krause, K., Schierhorn, A., Sinz, A., Wissmann, J.D., Beck-Sickinger, A.G., Paschke, R. and Führer, D., Toward the Application of Proteomics to Human Thyroid Tissue. Thyroid 16, 1131–1143 (2006) PubMed entry

Ihling, C., Schmidt, A., Kalkhof, S., Stingl, C., Mechtler, K., Haack, M., Schulz, D.M., Cooper, D.M.F., Beck-Sickinger, A.G. and Sinz, A., Isotope-Labeled Cross-Linkers and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Structural Analysis of a Protein/Peptide Complex. J. Am. Soc. Mass Spectrom. 17, 1100–1113 (2006) PubMed entry

Schmitt, A., Meiners, I., Schmitt, J., Nöller, J., Ihling, C., Münch, G., Sinz, A. and Nieber, K., Two analytical methods to study the interaction of AGEs with cell surface proteins. J. Biochem. Biophys. Methods 65, 121–136 (2005) PubMed entry

Sinz, A., Kalkhof, S. and Ihling, C., Mapping Protein Interfaces by a Trifunctional Cross-Linker Combined with MALDI-TOF and ESI-FTICR Mass Spectrometry. J. Am. Soc. Mass Spectrom. 16, 1921–1931 (2005) PubMed entry

Schmidt, A., Kalkhof, S., Ihling, C., Cooper, D.M.F. and Sinz, A., Mapping Protein Interfaces by Chemical Cross-Linking and FTICR Mass Spectrometry: Application to a Calmodulin/Adenylyl Cyclase 8 Peptide Complex. Eur. J. Mass Spectrom. 11, 525–534 (2005) PubMed entry

Ihling, C. and Sinz, A., Proteome Analysis of Escherichia coli using High-Performance Liquid Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Proteomics 5, 2029–2042 (2005) PubMed entry

Kalkhof, S., Ihling, C., Mechtler, K. and Sinz, A., Chemical Cross-Linking and High-Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Protein Interaction Analysis: Application to a Calmodulin/Target Peptide Complex. Anal. Chem. 77, 495–503 (2005) PubMed entry

Berger, K., Wissmann, D., Ihling, C., Kalkhof, S., Beck-Sickinger, A., Sinz, A., Paschke, R., Führer, D., Quantitative proteome analysis in benign thyroid nodular disease using the fluorescent ruthenium II tris(bathophenanthroline disulfonate) stain. Mol. Cell. Endocrinol. 227, 21–30 (2004) PubMed entry

Sinz, A. and Wang, K., Mapping Spatial Proximities of Sulfhydryl Groups in Proteins Using a Fluorogenic Cross-Linker and Mass Spectrometry. Anal. Biochem. 331, 27–32 (2004) PubMed entry

Schulz, D.M., Ihling, C., Clore, G.M. and Sinz, A., Mapping the Topology and Determination of a Low Resolution Three-Dimensional Structure of the Calmodulin-Melittin Complex by Chemical Cross-Linking and High-Resolution FTICR Mass Spectrometry: Direct Demonstration of Multiple Binding Modes. Biochemistry 43, 4703–4715 (2004) PubMed entry

Schulz, D.M. and Sinz, A., Chemisches Cross-Linking und Massenspektrometrie zur strukturellen und funktionellen Charakterisierung von Proteinen. BIOSpektrum 10, 45–48 (2004)

Sinz, A., Chemical Cross-Linking and Mass Spectrometry for Mapping Three-Dimensional Structures of Proteins and Protein Complexes. J. Mass Spectrom. 38, 1225–1237 (2003) PubMed entry

Sinz, A., Jin, A.J. and Zschörnig, O., Evaluation of the Metal Binding Properties of a Histidine-Rich Fusogenic Peptide by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J. Mass Spectrom. 38, 1150–1159 (2003) PubMed entry

Dihazi, G.H. and Sinz, A., Mapping Low-Resolution Three-Dimensional Protein Structures Using Chemical Cross-Linking and Fourier Transform Ion-Cyclotron Resonance Mass Spectrometry. Rapid Commun. Mass Spectrom. 17, 2005–2014 (2003) PubMed entry

Ihling, C., Berger, K., Höfliger, M.M., Führer, D., Beck-Sickinger, A.G. and Sinz, A., Nano-High-Performance Liquid Chromatography Combined with Nano-Electrospray Ionization Fourier Transform Ion-Cyclotron Resonance Mass Spectrometry for Proteome Analysis. Rapid Commun. Mass Spectrom. 17, 1240–1246 (2003) PubMed entry

Sinz, A., Bantscheff, M., Mikkat, S., Ringel, B., Drynda, S., Kekow, J., Thiesen, H.J. and Glocker, M.O., Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis., Electrophoresis 23, 3445–3456 (2002) PubMed entry

Sinz, A. and Wang, K., Mapping protein interfaces with a fluorogenic cross-linker and mass spectrometry: Application to nebulin-calmodulin complexes. Biochemistry 40, 7903–7913 (2001) PubMed entry

Kawamura, M., Eisenhofer, G., Kopin, I.J., Kador, P.F., Lee, Y.S., Tsai, J.-Y., Fujisawa, S., Lizak, M.J., Sinz, A. and Sato, S., Aldose reductase: A key enzyme in norepinephrine metabolism in rats. Biochem. Pharmacol. 58, 517–524 (1999) PubMed entry

Sinz, A., Matusch, R., van Elsaecker, F., Santisuk, T., Chaichana, S. and Reutrakul, V., Phenolic Compounds from Anomianthus dulcis. Phytochemistry 50, 1069–1072 (1999)

Sinz, A., Matusch, R., Kaempchen, T., Fiedler, W., Schmidt, J., Santisuk, T., Chaichana, S., Reutrakul, V. and Wangcharoentrakul, S., Novel Acetogenins from the Leaves of Dasymaschalon sootepense. Helv. Chim. Acta 81, 1608–1615 (1998)

Sinz, A., Matusch, R., Santisuk, T., Chaichana, S. and Reutrakul, V., Flavonol Glycosides from Dasymaschalon sootepense. Phytochemistry 47, 1393–1396 (1998) PubMed entry