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The research interest of our group is the advancement of the chemical cross-linking/MS strategy for elucidating protein 3D-structures and for mapping protein-protein interactions. We are currently exploring the development and application of novel MS/MS cleavable cross-linkers as well as the incorporation of photo-reactive amino acids. Analysis of the cross-linked products is performed by the StavroX software developed by Michael Götze. Our lab is equipped with two Orbitrap mass spectrometers (LTQ-Orbitrap XL and Orbitrap Fusion Tribrid, Thermo Fisher Scientific), both coupled to nano-HPLC systems, a MALDI-TOF/TOFmass spectrometer (Ultraflex III, Bruker Daltonik), and a High-Mass Q-TOF mass spectrometer (Micromass/MS Vision).